(Note: Another form of this gene is known to increase the activity of simvastatin as well as atorvastatin).Īlthough green tea can help lower cholesterol, it can also decrease absorption of some, but not all, statin drugs. Soy isoflavones were found to reduce the bioavailability of simvastatin by an average of 48% in people carrying a common form of the SLCO1B1 521 gene. However, some other statins do not seem to be affected by grapefruit juice, including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor). Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). Some fruit juices can also be a problem, particularly grapefruit juice, which impairs the body's normal breakdown of certain statins, allowing them to build up to potentially excessive levels in the blood.
Nevertheless, some physicians believe taking niacin in addition to statin medication may be helpful for certain people however do not try this combination without consulting your physician.
While high doses of niacin may help to lower cholesterol, studies show that if you already take a statin drug, adding high-dose niacin does not appear to provide additional benefit and may carry serious risks. Red yeast rice, which contains a naturally occurring statin, should not be combined with prescription statin drugs without medical supervision.īerberine should be avoided or used with caution when taking certain statin drugs, such as atorvastatin (Lipitor), lovastatin (Mevacor) and rosuvastatin (Crestor).
Certain forms of magnesium may also decrease blood levels of statin drugs - particularly Crestor. John's wort and possibly quercetin, may decrease blood levels of some statin drugs, and when taken with atorvastatin, may actually result in increased cholesterol levels. Atorvastatin (Lipitor), rosuvastatin (Crestor), and other cholesterol-lowering statin drugs can be affected by taking supplements and can affect your ability to absorb certain vitamins and minerals.
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